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TOXICITY-RELATED MORTALITY The only fluoropyrimidine-related death reported in DPYD carriers who were treated with a reduced dose occurred after the patient had been wrongly prescribed a standard fluoropyrimidine dose for two cycles

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One of the most significant of these is the activation of SIRT1, often called a “longevity gene.” SIRT1 helps manage insulin sensitivity and supports healthier blood sugar regulation, which is fundamental for sustained energy and preventing the metabolic strain that can lead to weight gain