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NAD+ Cycle Length Planning Examples Planning framework 4-week SubQ planning Loading or maintenance context Assessment or titration phase Review or adjustment point Review at week 4 Evidence type Community and clinic planning Planning framework 8-week SubQ planning Loading or maintenance context Titration followed by a regular planning phase Review or adjustment point Review at weeks 4 and 8 Evidence type Community and clinic planning Planning framework 12-week SubQ planning Loading or maintenance context Titration followed by maintenance planning Review or adjustment point Review every 4 weeks Evidence type Community and clinic planning Planning framework IV loading plus maintenance Loading or maintenance context 3-5 daily sessions, then weekly or monthly Review or adjustment point Review after loading and every 4-8 weeks Evidence type Supervised clinic practice Planning framework Continuous or ongoing planning Loading or maintenance context Frequency may be adjusted instead of using a fixed break Review or adjustment point Review every 4-8 weeks Evidence type Clinic and community planning NAD+ does not have to be cycled on and off

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