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In the cancer cell microenvironment, the intracellular GSH level becomes exceptionally high to fight against oxidative stress created by the production of ROS/RNS or any free radicals, which are the byproducts of intracellular redox reactions or cellular respiration processes

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The enzymatic activities of the GSTA, P, and T classes are substantially low or even negligible compared to GSTM2, while GSTM1 was slightly less effective than GSTM2