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While the aforementioned findings are primarily derived from preclinical models, such as CSE-treated animals or cells, they demonstrate the possibility of using natural products to intervene in COPD pathology by regulating macrophage metabolic imbalances

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Pharmacologic Inhibition of the Cystine/Glutamate Transporter Suppressed the Formation of Tertiary Lymphoid Structures Glutathione is essential for lymphocyte activation and proliferation, but lymphocytes lack Slc7a11 expression and have a low cystine uptake capacity