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The regulation of P-gp expression by natural products, synthetic compounds, RNA and biological compounds in humans involves a variety of mechanisms and molecular targets, such as the PI3K/AKT (51), MEK/ERK, Wnt/β-catenin and NF-κB/STAT3 (58) signaling pathways

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Antibodies against T-cell immunological negative regulators (PD1, PDL1, and CTLA4) directly boost the immune system, resulting in extraordinary clinical success in a range of malignancies and FDA approval of the following immune checkpoint targeted immunotherapies [109]