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The FDA has approved Tonmya, the first new fibromyalgia treatment in over 15 years. This non-opioid, bedtime sublingual tablet (cyclobenzaprine HCl) offers faster absorption and significantly reduced daily pain in Phase 3

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In parallel, in a recent randomized double-blind, placebo-controlled trial of abdominally obese individuals, pyridoxamine administration over 8 weeks reduced plasma methylglyoxal (MGO), protein-bound AGE MG-H1, and endothelial dysfunction markers such as sVCAM-1 and sICAM-1 [161]