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With the advancement of lineage tracing technology and single-cell spatial sequencing technology, it has been found that VSMCs can also generate various alternative cell types such as osteogenic/chondrogenic VSMCs, myofibroblast-like cells, endothelial cells, macrophage-like foam cells, and inflammatory VSMCs to constitute unstable plaques with inflammation and ossification or stable plaque states with collagen matrix deposition and calcification [15,16,17,18]
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