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In the absence of MyD88 signaling, several innate immune pathways are affected, such as the majority of TLRs (except TLR3), IL-1R, IL-18R, IL-33R/ST2, and IL-36R ( Our data suggests that the main role of MyD88 signaling in BCG-elicited antitumor response is to promote the recruitment and activation of antitumor immune cells into the TME as well as establishing an interplay between the innate and adaptive immune response through priming immune cells
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