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Precise regulation of cellular SAM pools is critical to maintain cellular methylation potential (often measured by the SAM:SAH ratio), where disruption of this potential leads to broad cellular perturbations including altered DNA 11–13 and histone methylation 14,15 , transcriptional dysregulation 14,16,17 , and impaired cell growth 18–21

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104 Translating MSCs or other stem cell-derived products from bench to bedside could offer a therapeutic avenue for PACS patients with neurological manifestations