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The mice were then randomly divided into five groups, namely, the Prdx2 +/+ (wild) control mice, Prdx2 –/– (knockout) control mice, Prdx2 +/+ mice treated with Imiquimod (IMQ), Prdx2 –/– mice treated with IMQ, and Prdx2 +/+ as well as Prdx2 –/– mice treated with Conoidin A and IMQ

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It means the effect is primarily local — concentrated in the GI tract, where the peptide is in direct contact with the tissue it needs to repair