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Frontiers | Effective Combinations of Immunotherapy and Radiotherapy for Cancer Treatment

[,] In animals, splenectomy attenuates concanavalin A (ConA)-induced hepatic fibrosis in mice by decreasing serum levels of TNF superfamily 14 (TNFSF14, or LIGHT), which can promote fibrosis through direct binding to TNFRSF3 (lymphotoxin β receptor, LTβR), but not TNFRSF14 (herpesvirus entry mediator, HVEM) on hepatic macrophages to increase JNK-mediated TGF-β1 expression

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The two prevalent chronic liver diseases are alcohol-associated liver disease (ALD) and metabolic dysfunction-associated steatotic liver disease (MASLD)