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Molecular Imaging of Diabetes-Associated Glutathione S‑Transferase Dysregulation Using a Smart Activatable Probe - ScienceDirect

Competitive or noncompetitive inhibition of P-gp efflux function represents the most direct method

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Therefore, SLC7A11 overexpression may promote tumor growth/survival but once the tumor is established, SLC7A11-high tumors are more sensitive to glucose or glutamine deficiency in the tumor microenvironment ( Figure 2 )