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Vetere G, Osterlund E, Yousef MM, Payapwattanawong S, Maddalena G, Alshenaifi JY, Alfaro K, Knafl M, Van K Morris II, Parseghian C, Wolff RA, Dasari A, Overman MJ, Kopetz S , YC Shen JP
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Ser is a substrate for mitochondrial oneβcarbon metabolism, which generates NADPH while converting Ser + tetrahydrofolate (THF) into glycine (Gly) + THF + formate through the activity of serine hydroxymethyl transferase 2 (SHMT2), methyleneβTHF dehydrogenase (MTHFD) 2, and MTHFD1L