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429 and (4) furthermore, key cytokines and growth factors essential for maintaining TEC function, including mesenchymal-derived KGF, macrophages and T lymphocyte-derived IGF-1, and thymic stromal cell-derived bone morphogenetic protein-4 (BMP4), as well as critical TEC functions such as the production of cytokines (e.g., IL-7 and Kit ligands) and chemokines (e.g., SDF-1 and TECK), can improve thymic function in mice