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(Kumar SK, Berdeja JG, Niesvizky R, Lonial S, Laubach JP, Hamadani M, Stewart AK, Hari P, Roy V, Vescio R, Kaufman JL, Berg D, Liao E, Di Bacco A, Estevam J, Gupta N, Hui AM, Rajkumar V, Richardson PG) Lancet Oncol 2014 Dec;15(13):1503-1512 261 Citations 2 Survival of patients with acute myeloid leukemia relapsing after allogeneic hematopoietic cell transplantation: a center for international blood and marrow transplant research study

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As a major fraction of glutamate recovered from the synapse is converted into glutamine in astrocytes (Figure 1), it has been hypothesized that diminished GS activity will lead to extensive intracellular astrocyte glutamate accumulation, which in turn reduces synaptic glutamate uptake, causing excessive neuronal excitability and seizures (Eid et al