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doi: 10.1093/rheumatology/37.7.779 67 BaroneFBombardieriMRosadoMMMorganPRChallacombeSJDe VitaSet al

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This is particularly relevant in patients with compromised immune function or chronic inflammation, where even low-level immunogenicity can lead to anti-drug antibody (ADA) formation and decreased therapeutic efficacy [271]