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• Large retrospective analysis, examined over 2000 general surgery patients receiving inhaled NAC therapy and found NAC was associated with a significantly lower incidence of postoperative pulmonary complications, postoperative intensive care unit admission, postoperative mechanical ventilation and need for sputum suctioning compared to a group receiving ambroxol therapy

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However, because of the narrow therapeutic window for acute liver injury and the side effects of NAC, its clinical application has great limitations (Du et al., 2016)