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Kynurenine is subsequently converted to NAD + in a chain of reactions with the rate-limiting step by quinolinic phosphoribosyltransferase (QPRT), which converts quinolinic acid into nicotinic acid mononucleotide (NAMN) 26 , finally entering the Preiss–Handler pathway

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[21] Nicotinic acid is prepared by hydrolysis of nicotinonitrile, which, as described above, is generated by oxidation of 3-picoline