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It has been noted that mtROS was a potent trigger for the activation of NADPH oxidase 2 (Nox2), leading to the activation and influx of myelomonocytes, and that mitochondrial H 2 O 2 stimulated T cells to increase tumor necrosis factor-α (TNF-α) production

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Darkening of the skin, especially across the knuckles, which has occasionally been the only presenting sign of early B12 deficiency