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In normal endometrial tissue, oestrogen may inhibit autophagy in the endometrium by inhibiting the hypoxia-inducible factor-1/ROS/AMP-activated protein kinase signalling pathway and further activating mammalian target of rapamycin complex (mTOR) signalling during nonmenstrual periods [100]

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Targeting fibrosis for the treatment of heart failure: a role for transforming growth factor-β