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GHS-R1a Receptor Binding The ghrelin receptor pathway differs fundamentally from GHRH signaling: Phospholipase C activation: GHS-R1a couples to Gq proteins, not Gs like GHRH-R Calcium influx: IP3-mediated calcium release triggers GH secretion Distinct somatotroph populations: Some research suggests GHRH and GHRP may target overlapping but non-identical cell populations Selectivity Advantage Ipamorelin's key research advantage is its selectivity profile