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All the animals were sacrifice at the end of the study to determine the gastric pH, gastric acidity, gastric ulcer score, haematological indices, superoxide dismutase (SOD) activity, reduced glutathione (GSH) and Lipid peroxidation (LPO) levels
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Proteolysis of abnormal CFTR transporter was suggested by tagging the protein with an "adaptor ligase" activating the ubiquitin - proteasome degradative pathway associated to ER named as ERAD [23,24]