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Weight reduction (denoted henceforth with the minus [-] sign) ranges from −2.8 to −4.8% total body weight loss (TBWL).55,56,70,87 Additional benefits of orlistat include reduced total cholesterol, LDL, fasting glucose, and systolic and diastolic blood pressure (Table 5).88–90 Side effects arise from the reduced fat absorption, including flatulence, fecal urgency, fecal incontinence, and fat-soluble vitamin deficiencies, which result in high rates of treatment discontinuation, and low clinical use.87,91 Table 5

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doi: 10.1007/s10571-019-00696-2