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A whole-body model for glycogen regulation reveals a critical role for substrate cycling in maintaining blood glucose homeostasis

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Chronic inflammatory enteropathies Chronic inflammatory enteropathies (CIE), further classified based on the response to treatment as either food‐responsive enteropathy, antibiotic‐responsive enteropathy, immunosuppressant‐responsive enteropathy (IRE), or nonresponsive enteropathy (NRE), are characterized by chronic persistent or recurrent clinical signs of GI disease (such as vomiting, diarrhea, weight loss, or a combination of those) for longer than 3 weeks and are diagnosed retrospectively based on the response to treatment.65, 71 It has been postulated that chronic mucosal disease affecting the ileum reduces the epithelial expression or function of the cubam receptor leading to a reduced mucosal uptake of cobalamin