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The human zinc-binding cysteine proteome - ScienceDirect

Apart from viral infections [82], multiple factors can cause degradation of the GL, including major surgery, ischemia/reperfusion, hypoxia/reoxygenation, mechanical ventilation [3, 48, 69], sodium overload [64, 80], ox-LDLs [5, 40, 86], sepsis, haemorrhagic shock, excessive shear stress, hypervolemia [48, 49], hyperglycaemia [68, 80], inflammatory cytokines such as tumour necrosis factor α (TNF α ) [5, 85], interleukin (IL)-1 β , IL-6, and IL-10 [48, 57, 58], matrix metalloproteinases (MMPs) [64, 65, 87], and reactive oxygen/nitrogen species [6]

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2) and some loops at the surface