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Acetyl-CoA synthetase 2, which generates acetyl-CoA, can act on chromatin and directly modulate histone acetylation in hippocampal neurons, which has been shown to subsequently regulate memory-related neuronal genes and affect long-term spatial memory in mice

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Effects of crocin and saffron aqueous extract on gene expression of SIRT1, AMPK, LOX1, NF-κB, and MCP-1 in patients with coronary artery disease: A randomized placebo-controlled clinical trial