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After incubation, the media were removed, and 300 µM of H 2 O 2 was added to the wells followed by 6 h incubation

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In monocytes and macrophages, caspase-1 activates caspases-3/7 and induces apoptosis in the absence of GSDMD while caspases-3/7 specifically block pyroptosis by cleaving GSDMD during apoptosis, which is called “bidirectional crosstalk” [169]