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1998 foundational paper reported GHS-R1a binding in the low-nanomolar range and growth hormone release from primary rat pituitary cells, anesthetized rats, and conscious swine at potencies comparable to GHRP-6, while plasma ACTH, cortisol, prolactin, FSH, LH, and TSH were not detectably elevated at doses 200-fold above the GH ED50 [4]