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In addition, Metformin hydrochloride regulates the expression of autophagy -related proteins by activating AMPK and inhibiting the mTOR signaling pathway, thereby inducing tumor cell autophagy and inhibiting the growth of renal cell carcinoma in vitro and in vivo

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doi: 10.1172/JCI8814 31 DingLSunWBalazMHeAKlugMWielandSet al