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The persistence of maladaptive memory: addiction, drug memories and anti-relapse treatments

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To investigate the role of USCs in bladder remodelling, we isolated bladder USCs from convalescent mice (4 weeks after the initiation of antibiotics), from both those with self-resolved infection (resolved) and those that developed chronic infection (sensitized), as well as from age-matched naïve mice as controls and established USC lines ( n = 4 per infection history) (Fig