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Adipose tissue is distributed throughout the body, including in subcutaneous tissue, the retroperitoneal space, and in close proximity to organs such as the heart

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In this model, the E3 ligase tumor necrosis factor receptor-associated factor 6 (TRAF6) promotes k63-linked ubiquitination of krϋppel-like transcription factor 5 (KLF5) and facilitates the interaction of KLF5 with downstream molecules, which provides a new possibility for a therapeutic approach to MsPGN[10]