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It also diminished induction of TNF-α and IL-6, decreased NF-κB nuclear translocation and p38 mitogen activated protein kinase phosphorylation, abolished intracellular hydrogen peroxide production, restored intracellular thiol levels, and reduced virus titre
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Therefore, a meta-defencor targeting mitochondria has been developed, which scavenges mtROS and suppresses mitochondrial nitric oxide synthase, thereby increasing mitochondrial transcription factor A expression, restoring aerobic respiration, and reprogramming mitochondrial metabolism for the conversion of M1 macrophages to M2 macrophages (135)