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However, this idea, while demonstrating the ameliorative effect of vagus nerve excision on the association with obesity (101), is limited by the absence of significant changes in some lean animals and some populations (98), as well as the increased occurrence of secondary trauma and mortality after excision (102)

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This approach further enhances STING signalling and remodels the immunosuppressive TME, offering a more promising therapeutic strategy for inhibiting tumour growth, metastasis, and postoperative recurrence