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Current laboratory investigations further evaluate intracellular signaling involving TGF-β , MAPK/ERK , PI3K/Akt , NF-κB , matrix metalloproteinases (MMPs) , tissue inhibitors of metalloproteinases (TIMPs) , copper-dependent enzymes, and additional molecular systems associated with extracellular matrix regulation and peptide signaling

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Hepatology 73, 783–793