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To a considerable extent, the missing in-depth knowledge of metabolic host responses to bacterial infections is due to the fact that the elucidation of the metabolic changes in the host and the bacterial pathogen during infections poses major experimental challenges in terms of the infection models and the analytical methods (discussed in some detail in the text below)

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Yet, a large number of clinical trials have failed to show beneficial effects of antioxidants for these pathologies, and a handful of trials have suggested that antioxidants increase mortality