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Notably, miR-663a was among the most severely down-regulated genes

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17 , 18 The impact of cataract on impaired vision is much greater in less-developed countries, where more than 90% of the cases of blindness and visual impairment are found 14 , 21 , 22 , 23 , 24 , 25 and where there is a dearth of ophthalmologists to perform lens extractions