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Figure 1 2 Search strategy The following keywords were used for searches of publications published from 2014 to 2024 in Chinese and English databases, including China National Knowledge Infrastructure (CNKI), PubMed, and Web of Science (SCIE): βsciatic nerve injury,β βanimal models,β βChronic constriction injury,β βPartial sciatic nerve ligation,β βSpared nerve injury,β βSciatic nerve crush injury,β βSciatic nerve transection,β βtreatment of sciatic nerve,β βNeurotrophic agents,β βAntioxidant,β βAnti-inflammatory,β βTissue engineeringβ and βstem cell therapy.β In addition to focusing on the relevant articles between 2014 and 2024, we also traced many of the original literature on sciatic nerve injury modeling methods to ensure a comprehensive understanding of sciatic nerve injury modeling (Figure 2)