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Adapted from references (1,3–7) GH binds to the extracellular component of the hepatic GH receptor (GH-R) and induces a series of intracellular processes required for the transcription and translation of specific genes that encode insulin-like growth factor 1 (IGF1), IGF-binding protein 3 (IGFBP3), and an acid-labile subunit (ALS)(8–10)