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Moreover, the Wnt/β-catenin signaling antagonist DKK4 was a target gene of the EDA/EDAR/NF-κB pathway, serving as a negative feedback to limit β-catenin signaling ( Mutations or expression levels of APC and β-catenin levels were found to control the outcome of TLR4 activation by LPS on proliferation of colon cancer cells ( APC mutated or depleted cells but inhibited cell proliferation in APC wild-type cells

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307 , G397–G409 (2014)