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Furthermore, factors such as calcitonin gene‐related peptide (CGRP), α‐melanocyte‐stimulating hormone (α‐MSH), Substance P (SP), vasoactive intestinal polypeptide (VIP), macrophage migration inhibitory factor (MIF), indoleamine2,3‐dioxygenase (IDO), thrombospondin 1 (TSP1), and IK cytokine (Red/IK) are also involved in inhibiting the expression of MHC‐I classes through immune regulation, thereby serving a similar purpose [17, 91‐ 93 ]