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the patient be closely monitored, and the rise in creatinine should remain within an acceptable range ( In a retrospective study of 213 metastatic renal cell carcinoma (mRCC) patients treated with first-line sunitinib at Gustave Roussy (2004–2013), hypertension was associated with longer overall and progression-free survival, while the use of angiotensin system inhibitor (ASI) independently conferred significant benefits in both outcomes