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An imbalance between the pro-death and pro-survival proteins (also known as pro-apoptotic and anti-apoptotic proteins, respectively) can trigger downstream proteins in this pathway, leading to DNA fragmentation and cell death

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For oxidative stress conditions, lactate dehydrogenase (LDH) release in the cell culture medium was also measured via a Cytotoxicity Detection Kit reaction mixture (Roche Diagnostics, Meylan, France) according to the manufacturer’s instructions