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Between 5–20% of each lysosomal enzyme synthesized escapes the lysosomal trafficking pathway and is directed to the secretory pathway (Figure 1C) for extracellular secretion [18, 19, 24, 25] (Figure 1C 1 )

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Pre-existing Conditions: Individuals with liver or kidney disease should be particularly cautious and seek professional guidance, as these organs are the primary sites for amino acid metabolism