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In cases where blood vessels malfunction, like in DR, FSP1 may play a role in controlling the growth of extra blood vessels and the formation of tough scar tissue by communicating with growth factors and the cell surface receptors, which in turn affects how the extracellular matrix changes and the series of events that lead to new blood vessel formation
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hypertension, type 2 DM, dyslipidemia) A meta-analysis of 22 trials involving over 17,000 patients determined that 50.2% and 17.5% of patients treated with GLP-1RAs (exenatide, semaglutide & liraglutide) experienced a weight loss of ≥5% and ≥10% compared to placebo, and that patients without type 2 diabetes achieved a significantly greater weight loss compared to those with diabetes (Vosoughi et al, 2022)
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