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Constipation is less dose-dependent and can persist, making it a more durable reason for discontinuation in patient reports.⁸ ²³ Sulfur burps reflect food sitting longer in a slowed stomach.⁹ ²³ Fatigue ranks second only to nausea in patient forums, although much of it tracks the calorie deficit rather than tirzepatide itself.²³ Fried or fatty foods, coffee, meat, and alcohol can also become less appealing