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The exclusion criteria were the following: articles (I) that do not evaluate the toxicity/safety of PHMG, for example, articles devoted to the study of compositions containing PHMG, or various modifications of PHMG, with the exception of various salts of PHMG, as well as articles studying regimens for the relief of pathological symptoms caused by exposure to PHMG, as in the study "Anti-fibrotic effect of Pycnogenol® in a polyhexamethylene guanidine-treated mouse model"