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Similarly, in a previous study with HFD-fed WT and RAMP1/3 KO mice, we also observed that sCT-treated WT mice gained weight, whereas RAMP1/3 KO mice experienced weight loss, followed by minimal weight regain by the end of the treatment period

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Thus, part of the resistance of PDHC to thioacylation/inactivation in kidney mitochondria of TFEC-treated rats may be due to differences in the arrangement of its constituent enzymes within the enzyme complex